Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV
| PAG Title | Down-regulated at 8 h following infection of primary human foreskin fibroblasts with CMV |
| PAG ID | MAX003381 |
| Type | A |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Mechanistic insights to viral replication and pathogenesis generally have come from the analysis of viral gene products, either by studying their biochemical activities and interactions individually or by creating mutant viruses and analyzing their phenotype. Now it is possible to identify and catalog the host cell genes whose mRNA levels change in response to a pathogen. We have used DNA array technology to monitor the level of approximately 6,600 human mRNAs in uninfected as compared with human cytomegalovirus-infected cells. The level of 258 mRNAs changed by a factor of 4 or more before the onset of viral DNA replication. Several of these mRNAs encode gene products that might play key roles in virus-induced pathogenesis, identifying them as intriguing targets for further study. |
| Species | Homo sapiens |
| nCoCo Score | 55 |
| Base PAG ID | MAX003381 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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